1. What is APTT mixing study？
APTT (Activated Partial Thromboplastin Time) mixing study is an experiment that mixes patient plasma (PP) and normal pooled plasma (NPP) according to a certain ratio and then detects APTT multiple times to evaluate the degree of APTT “correction” in mixed plasma, which can be used to confirm the diagnosis Guidance is provided in the selection of trials.
2. Possible clinical performances of APTT prolongation
In general, prolonged APTT is often observed in the following situations:
a）Excessive bleeding，such as hemophilia A, hemophilia B, pseudo von Willebrand disease, acquired hemophilia, etc.
b）Risk of thrombosis, such as patients with LA (lupus anticoagulant), positive antiphospholipid antibodies, etc.
c）No clinical performances, such as deficiencies in coagulation factors in the exposure system, are more common in factor XII deficiency.
3. What clinical problems can APTT mixing study solve?
Although the APTT mixing study is a screening test, it can help the clinicians choose the direction of the next diagnostic examination and reduce the medical burden on patients. It is especially valuable for primary hospitals that have not carried out coagulation factors, lupus anticoagulants and other projects. The APTT mixing study can identify the prolongation of APTT caused by coagulation factor deficiency, factor VIII inhibitors or other inhibitors. Combined with A preliminary diagnosis was made based on the patient’s past medical history and clinical performances.
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Automated Coagulation Analyzer MC550 Features：
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- Automatic operation, streamlined workflow, save cost and time, high diagnostic efficiency
- Less sample volume (90uL), higher throughput, increased cost-efficiency
Post time: Feb-08-2023